BIOL1130 Lecture Notes - Lecture 1: Senescence, Sirtuin 1, Sirtuin
Document Summary
Cellular dna is wrapped around a complex of packaging proteins called histones. These bear chemical tags, such as acetyl groups, that determine how snugly the histones package dna. Sir2 and nad was exciting due to how it linked sir2 to metabolism as well as how diet is linked to aging seen in calorie restriction. The calorie connection in sir2 restricting an animal"s calorie intake is the most famous intervention one absolutely proven to work. On one hand, calorie restriction turns on a gene called pnc1, which produces a nicotinamidase that rids cells of nicotinamide, a small molecule similar to vitamin b3 that normally represses sir2. Consistent with the idea that calorie restriction is a stressor that activates a survival response, It turns out that not only does nad activate sir2 nadh is an inhibitor of. Sirt2 enzyme, so altering the cell"s nad/nadh ratio greatly influences. Sir2 activity: however, fanatic dieting is not a reasonable option.
