NURS-2144EL Lecture 3: Lupus

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22 Feb 2022
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* chronic , multi system inflammatory disease associated with abnormalities of immune system results from interactions among genetic , hormonal , environmental , and immunological. Sle affects 1 per 1000 people in canada nine times more likely in women than men has effects on : skin , joints , serous membranes , renal system , hematological system , neurological system etiology and pathophysiology. > etiology is unknown most probable causes : autoimmune reactions directed against constituents of cell nucleus . Dna antibody response related to b- and t-cell hyperactivity clinical manifestations & complications ranges from a relatively mild disorder to rapidly progressive , affecting many body systems. * most commonly affects the skin and muscles , lining of lungs , heart , nervous tissue , and kidneys derm : alopecia , butterfly rash , discoid erythema , palmar erythema , mucosal ulcers. Cns : stroke , seizures , peripheral neuropathy , psychosis , organic brain syndrome.

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