PHARMACOLOGY Study Guide - Quiz Guide: Partial Thromboplastin Time, Antithrombin, Thromboxane A2
Document Summary
Activated partial thromboplastin (aptt) test laboratory test used to monitor the anticoagulant effect of unfractionated heparin and direct thrombin inhibitors; prolonged when drug effect is adequate. Antithrombin iii an endogenous anticlotting protein that irreversibly inactivated thrombin and factor xa. When activated, it aggregates platelets primarily by binding to fibrin. Endogenous factors including thromboxane a2, adp, and serotonin initiate a signaling cascade that activates dpiib/iiia: heparin-induced thrombocytopenia (hit) a hypercoagulable state plus thrombocytopenia that occurs in a small number of individuals treated with unfractionated heparin. Fractionated preparations of heparin of molecular weight 2000-6000: unfractionated heparin has a molecular weight range of. Prothrombin time (pt) test laboratory test used to monitor the anticoagulant effect of warfarin; prolonged when drug effect is adequate. Two groups of drugs used in clotting and. Bleeding disorders: drugs used to decrease clotting or dissolve clots already present in patients at risk for vascular occlusion, drugs used to increase clotting in patients with clotting deficiencies.
