PHA 3112 Chapter Notes - Chapter 52: Deep Vein Thrombosis, Disseminated Intravascular Coagulation, Epidural Hematoma
10 Dec 2016
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Document Summary
Hemostasis: physiologic process where bleeding is stopped; 2 stages triggered by blood vessel injury: formation of a platelet plug, , reinforcement of platelet plug with fibrin. Stage one: formation of a platelet plug: platelet contacts collagen on exposed surface of damaged blood vessel , platelet aggregation initiated , platelets adhere to site of vessel injury adhesion initiates platelet activation , leads to massive platelet aggregation. Platelet aggregation: a complex process that ends with formation of fibrinogen bridges btw glycoprotein iib/iiia (gp iib/iiia) receptors on adjacent platelets; unstable plug reinforced w/ fibrin. Treatment of hemostasis: antithrombin (protein inhibit clotting factors) cause body inactivate any clothing factors stray from injury. Injured bv healing requires clot removal caused by plasmin (enzyme degrades fibrin meshwork of clot) Plasmin: produced through activation of plasminogen (precursor) Thrombus: permanent blood clot formed within blood vessel (either an artery or vein) or within heart. Consequence of arterial thrombus: localized tissue injury owing to lack of perfusion.
