BIO 360 Chapter : Module 5_ Lesson 1 Nucleotides Structure and Function

QUESTION 1. Compared to eukaryotic genomes, only prokaryotic genomes:

QUESTION 2. Azathioprine is a drug that may be prescribed to transplant recipients to reduce the chance of tissue rejection reactions. In its active state, it acts as a purine analogue, inhibiting DNA biosynthesis. This means that 6-mercaptopurine will be inserted in place of a purine containing nucleotides during DNA replication. Given this drug's mode of action, you would expect it to be incorporated into DNA in place of:

QUESTION 3. RNA is distinguished from DNA because only RNA:

QUESTION 4. How are RNA nucleotides different from DNA nucleotides? To be marked correct, you'll need to select all true statements, as there may be more than one correct answer.

How can nucleotides found in RNA be discriminated from those found in DNA?

a. RNA nucleotides contain ribose

b. RNA nucleotides are never purines

c. RNA nucleotides are never pyrimidines

d. RNA nucleotides may contain uracil

e. RNA nucleotides lack a 3’hydroxl group

f. RNA nucleotides never contain thymine

Discuss the difference between the de novo biosynthesis of purine nucleotides and the de novo biosynthesis of pyrimidine nucleotides. (Be creative). Example: purine biosynthesis requires much more energy - 8 ATP per purine NMP.