CAS PS 333 Lecture Notes - Lipophilicity, Adme, Grapefruit Juice

25 views5 pages

Document Summary

Learn about absorption of drugs: cell membranes, routes of drug administration, and subsequent absorption. Learn about the distribution of drugs: which factors affect distribution in the body and what role does the blood brain barrier play. Pk what the body does to the drug (adme) Absorption: how does it get into the blood. Distribution: where does it go in the body. Cells and membranes: absorption: cell membranes made of lipids, depending on route of administration, a drug may pass several membranes. Role of water: allows for dissolution of compounds; acts as vehicle to transport compounds. Lipid membranes: gasses and hydrophobic/ lipophilic molecules with pass more readily, small polar molecules pass through gaps, large polar molecules and charged molecules are repelled by membrane. The effects of a drug depend on how efficiently a drug can cross these membranes. Capillaries: substances enter bloodstream through capillaries, lipid soluble drugs diffuse readily through membrane, lipid insoluble drugs slip through the cracks diffuse through pores.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions