PHARM D Lecture Notes - Lecture 6: Hand Washing, Neuroscience, Pharmacotherapy
Document Summary
Obsessive-compulsive disorder: obsessive-compulsive disorder (ocd) is described as an anxiety disorder. Obsessions: repetitive thoughts (eg, feeling contaminated by germs, fears of harming others, repetitive images (eg, recurrent sexually explicit pictures, repetitive urges (eg, need for symmetry or putting things in specific order) Compulsions: repetitive activities (eg, hand washing, need to ask, need to confess, repetitive mental acts (eg, counting excessively, repeating words silently, praying) Antidepressant therapy: ssris and clomipramine are the main antidepressants used in ocd treatment, moa- ssris and clomipramine inhibit 5-ht reuptake into the presynaptic neuron, making more. 5-ht available to postsynaptic receptors and reducing formation of the 5-ht metabolite 5- hydroxyindoleacetic acid: side effects -ssris are less likely to cause cardiovascular, sedative, anticholinergic, and weight-gain side effects, and to reduce the seizure threshold. Clomipramine, however, is less likely than ssris to cause insomnia, akathisia, nausea, and diarrhoea: dose.