BIOL 2005 Lecture Notes - Lysosome, Antibody, Nadph Oxidase
30 Jan 2013
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Document Summary
Innate immunity rapid (minutes/hours), generalized response to injury. Features: primary response shares effectors w/ adaptive immunity; stimulates adaptive immunity recognizes molecular patters (as opposed to structural patterns) Invariant receptor classes (as opposed to recombined) appears in jawed vertebrates. Tlr"s toll like receptors transduce pamp signal into effector cell trigger at least 2 signal transduction cascades. Macrophages long lived kill bacteria and regulate inflammation cytokine secretion can present antigens. Roi and no both arise from myeloid progenitor cells (which came from pluripotent hematopeoetic stem cell) Neutrophils mature in bone marrow and released into blood adhere/diapedese through tissue kill pathogens by phagocytosis and use of ros/degradative enyzmes all activities are cytokine regulated. Macrophages can live in tissue for >1 month interact w/ adaptive immune system can remodel tissue can kill pathogens. Leukocyte circulation/migration: rolling (loose adhesion) mediated by selectins (p/e) on epithelium; l on leukocytes. Ligands are neutrophil cho"s: cytokine activation of both leukocyte and epithelial cells, tight adhesion stops rolling.
