BIOSC 0715 Lecture Notes - Lecture 19: T Helper Cell, Mhc Class Ii, Mhc Class I
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17 May 2017
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Lymph nodes filter what is brought to them and scan for antigens. Major histocompatibility class ii carries antigens on macrophages (mhc ii) T cells mature in thymus, b cells mature in bone marrow. B cells: t helper cells bind to antigens on b cells and stimulates clonal reproduction of b cells, produce antibodies, proteins, 4 chains of polypeptides joined by disulfide bonds, heavy chains = longer, diversity segments. Joining segments: both contain constant and variable regions, constant regions immunoglobulins. Igg, iga, igm, ige, igd: variable - match an antigen or epitope, allows for antigen specificity, can be some wiggle room, humoral response, on subsequent exposure to the pathogen, the secondary response is faster & larger. If you have any of these = rh positive: rh+ (has the d antigen on rbc) If not = rh negative: rh- (does not have the d antigen) Key observation: dna may be able to recombine, not always one single possible sequence.
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Immunology worksheet help?
1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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