BIOSC 0715 Lecture Notes - Lecture 20: Innate Immune System, Cas9, Ribonuclease Iii
17 May 2017
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Document Summary
Crispr/cas 9 a primitive and selective immune response. Spacers also called crrna: viral genetic material put into bacterial chromosome. Tracrrna (guide rna) & crrna: recruits cas9 and matches up to viral gene. Bacteria recognizes viral dna as non-self and put it into crsipr, which serves as a memory of previous infections. On first exposure to virus, cas complex (cas1, cas2, csn2) cut the viral dna and form it into a spacer. On second exposure to virus, tracrrna and cas9 are translated to scan the viral dna to find the sequence. Rnase iii is a participant in assembling guide rna and adding with viral dna. In bacteria, mission accomplished when viral dna has been destroyed no infection. O(cid:374) the se(cid:272)o(cid:374)d i(cid:374)jury at the sa(cid:373)e lo(cid:272)atio(cid:374) o(cid:374) a patie(cid:374)t"s ar(cid:373), the respo(cid:374)se (cid:271)y the innate immune system will be faster and stronger.
