BIO200H5 Lecture Notes - Lecture 8: Body Fluid, Enzyme, Neostigmine
Document Summary
We need to be absorbing molecules all the time so we also need to be eliminating. You can estimate half life here (real world graph) = tbc in kidney or liver (or a combination) Overdose of sa will make a pseudo-zero order. We can never get co because equilibrium takes time. When finding k, use slope from this graph (semi-log plot) It is reverse image of when we"re dosing (adding molecule goes up then levels off) When concentration is high in blood, kidney and liver work efficiently - routes of elimination. Proportion of elimination increases, but the absolute # molecules being eliminated decreases. Applied to drugs (calculating how much drug is eliminated) Elimination rate (proportion/ percent of drug eliminated per unit time) Body fluid is clear of drug (calculating how many leaders are cleared) Tbc: total body clearance sum of all clearance = cl (hepatic) + cl (renal)
