MCDB 310 Lecture Notes - Van Der Waals Force, Refueling And Overhaul, Carboxylic Acid

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 310
• Professor: Kenneth Balazovich

Document Summary

Binding site has positive charge to stabilize substrate = structure and function correlation. Example of protein that is used for transport is hemoglobin: rna can also carry out catalysis (example is ribosome) Functional groups involving oxygen: roh alcohol or hydroxl group, rcoh ketone group or carbonyl, rcor2 aldehyde group or carbonyl, rcooh carboxyl group. Functional groups involving hydrogen like to be part of a membrane don"t like to interact with water. Functional groups involving sulfur: sulfhydryl aka thiol group, disulfide hydrogen is eliminated through oxidation from the thiol group. Lots of functional groups within one molecule. Usually have to provide an enzyme in the body to make configuration stereoisomers. Rotation around double bond not possible: have to break then make again after rotation, this is not easy to do (have to invest a lot of energy) Example of where we would see fixed spatial arrangement: cis = same side, trans = opposite sides, these will not spontaneously interconvert.