PSIO 303A Study Guide - Brain-Derived Neurotrophic Factor, Neurotrophin-3, Autophosphorylation
20 Jan 2014
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Document Summary
Growth factors: in vitro and in vivo responsible for proliferation and how they influence adulthood: required for, proliferation - increase , fibroblast gf (fgf) + Insulin -like gf (igf-1) : hepatocyte gf (hgf) , transforming gf beta - tgf-b from bmp"s family , myostatin - stop proliferation, stop muscle production, differentiation - turn in to something specific. Igf-1 : tgf - b , myostatin - stop differenciation, quiescence - mucsle nuclei replace itself every 6 months, myostatin, tgf-b. Where do all factors come into play in the cell cycle: g1 - growth, check point - proliferation - fgf, g0 - leave cell cycle - neurons do not duplicate, muscle cells also can hang in here - Differentiation or quiescence (igf: g2 - preparation for division, s - synthesis of chromatin - proliferation - fgf, mitosis - yeilds 2 daughter cells.
