BIO SCI D103 Lecture Notes - Lecture 5: Intermediate Filament, Heteroplasmy, Nuclear Dna
18 Mar 2014
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Phenotype also depends on the identity of the cell. Is it possible to predict mitochondrial mutation pedigree: mito mutations i. ii. More pronounced in tissues with high energy requirement. Can occur in both the mtdna and ndna: mitochondria produce 13 proteins, has 22 trna. Cytoplasmic vs maternal inheritance: loss of profilin. Mitochondria: power plant of the cell, maternal inheritance i. Mitochondrial diseases: heteroplasmy, threshold effect i. ii. i. ii. i. ii. iii. i. i. Mutant and wt forms of mtdna in the same cell. Diseases may only be manifested if the % of mutant mtdna reaches a level (different between tissues) Same mtdna mutation can make different: moving cell that chases after bacteria. Follows a chemical signal released by the bacteria. Cytoskeleton: structure, stability, promotes movement within and of the cell. Look at image - determine which cytoskeleton it is b. c. 1. i. ii. ii. iii. ii. ii. ii.
