LIFE 210 Lecture Notes - Protein Structure, Carboxylic Acid, Dehydration Reaction
Document Summary
Last step in gene expression, are final product. Constitute most of the dry mass of cells. Protein structure and function builds directly on the concepts and principles we covered in lectures 1 4. Carbon central c of amino acid. Positive charge on amine group end, negative charge on carboxyl group end. Hydrocarbon chain bends back and bonds covalently to n of amine group. Forms disulfide bonds stabling structures for proteins. Some polar r groups are charged at the appropriate ph. Peptide bonds link amino acids dehydration synthesis. Between c of carboxyl group & n of amine group. Electrons jump back and forth c=o or c=n. 20n possible sequences, where n = # a. a. Can be amphipathic (hydrophilic on one side, hydrophobic on the other) Sheet made up of -strands (extended polypeptides) Between strands & sheets, between helices or between sheets & helices. Folding of 2 structure into a stable 3d form. Stabilized by h-bonding, ionic bonds, van der waals interactions.
