CHEM 4060U Lecture Notes - Abo Blood Group System, Pernicious Anemia, Serum Iron

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periwinklellama189

31 Jul 2012

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Nigerian journal of physiological sciences 21 (1-2):9-14 physiological society of nigeria, 2006. Serum iron and total iron binding capacity levels among. The abo blood groups in enugu, south eastern nigeria. 1 physiology department college of medicine university of nigeria, enugu campus enugu, nigeria. School of medical laboratory sciences, university of nigeria teaching hospital enugu. Summary: iron deficiency anaemia is a common tropical disease. Iron plays a very important role in the human body. The understanding of the different blood groups ability to retain iron in their system can give an insight into their ability to handle the disease iron deficiency anaemia. Iron binding capacity (tibc) and percentage transferrin saturation (%ts) levels were studied in. 2260 apparently healthy nigerian volunteers in enugu, eastern nigeria. The abo blood groups of the subjects were also determined. They were aged between 10 and 25 years, males were 1808 and females. 452 (m/f ratio- 8:2). in all the results obtained, the females had lower values.

Related Questions

The Henderson-Hasselbalch equation relates the pH of a buffer solution to the pKa of its conjugate acid and the ratio of the concentrations of the conjugate base and acid. The equation is important in laboratory work that makes use of buffered solutions, in industrial processes where pH needs to be controlled, and in medicine, where understanding the Henderson-Hasselbalch equation is critical for the control of blood pH.

Part A

As a technician in a large pharmaceutical research firm, you need to produce 100. mL of a potassium dihydrogen phosphate buffer solution of pH = 6.99. The pKa of H2PO4â is 7.21.

You have the following supplies: 2.00 L of 1.00 M KH2PO4 stock solution, 1.50 L of 1.00 M K2HPO4 stock solution, and a carboy of pure distilled H2O.

How much 1.00 M KH2PO4 will you need to make this solution? (Assume additive volumes.)

Express your answer to three significant digits with the appropriate units.

Volume of KH2PO4 needed =

______

PART B

The Henderson-Hasselbalch equation in medicine

Carbon dioxide (CO2) and bicarbonate (HCO3â) concentrations in the bloodstream are physiologically controlled to keep blood pH constant at a normal value of 7.40.

Physicians use the following modified form of the Henderson-Hasselbalch equation to track changes in blood pH:

pH=pKa+log[HCO3â](0.030)(PCO2)

where [HCO3â] is given in millimoles/liter and the arterial blood partial pressure of CO2 is given in mmHg. The pKa of carbonic acid is 6.1. Hyperventilation causes a physiological state in which the concentration of CO2 in the bloodstream drops. The drop in the partial pressure of CO2 constricts arteries and reduces blood flow to the brain, causing dizziness or even fainting.

If the normal physiological concentration of HCO3â is 24 mM, what is the pH of blood if PCO2 drops to 29.0 mmHg ?

Express your answer numerically using two decimal places.

pH =

_______

CHEM 4060U Lecture Notes - Abo Blood Group System, Pernicious Anemia, Serum Iron

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