BIOL 311 Lecture Notes - Tumor Suppressor Gene, Brca2, Exon
22 Nov 2012
School
Department
Course
Professor
Document Summary
Disease where cells in the breast grow and divide uncontrollably creating a tumor. Common forms include ductal (carry milk to nipple) or lobular (glands that produce milk) cancer. Symptoms: lump, discharge, size or shape change, tenderness, dimpling, and scaliness. (hard to identify) Brca1/brca2 genes most strongly associated with the development of breast cancer. Major contributors to increasing the risk acquiring the disease. Inherited in multiple genes that are linked with breast cancer when mutations arise. Can be due to mutations in brca2 gene in an autosomal dominant pattern. Not all people who inherit the mutated brca2 gene will develop breast cancer, it only increases the risk of development. Official name: breast cancer 2, early onset. Tumor suppressor gene that prevents rapid cell growth and division. Other functions to be determined possible contributor to regulation of cytokinesis during cell replication. Acrocentric on the long arm of chromosome 13 at position 12. 3 (13q12-q13) Exon 11 extremely large with 4932 nucleotides.
