HUMB1004 Study Guide - Final Guide: Hyaline Cartilage, Synovial Joint, Aggrecan
4 Aug 2018
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Avascular- no direct blood supply poor healing capacity. Chondrocytes are immobile which adds to the poor healing capacity. Unable to be seen on radiographs lacks hydroxyapatite crystals (so it is not dense enough) If cartilage is destroyed then the surrounding bone would have to be modified to resist certain pressures. Intracellular h20 = 60-80% provides compressive resistance. Glycoproteins = 5% adheres chondrocytes to ecm. Cells = 5% secretes the ecm. Proteoglycans = 10% hyaluran, aggrecan attracts water by exerting osmotic pressure. Has a tendency to calcify later in life. Physis precursor for bone before it is ossified. Low friction surface co-efficent of friction = 0. 001. Ecm looks amorphous mostly type 2 collagen. Pericondrium mostly type 1 collagen (secreted by fibroblasts) Contains cartilage precursor, which migrate from here and assist cartilage to grow. Ecm = type 1 + type 2 collagen much stronger. Hyaline cartilage + fibroblasts + type 1 collagen perichondrium.
