PHRM30003 Study Guide - Final Guide: Phosphodiesterase 4, Alpha-1 Antitrypsin, Mepolizumab
5 Jun 2018
School
Department
Course
Professor
Drug name
Drug class
Molecular target(s)
Mechanism/Function
Contradiction/AE/Notes
CF
/IPF
SABA/LABA
Bronchodilators
As for asthma
Inhaled hypertonic
saline +
Mannitol
Clear mucous?
DNase
-
alpha
(Pulmozyme)
Degrades bacte
rial DNA
Reduce mucus viscosity
Helps to thin the mucus
Combine with other therapy
Ibuprofen
NSAIDs
Oral
High dose
Cheap and old
Tobramycin
(TOBI)
Antibiotics
Inhale
bacterial ribosome
Inhaled aminoglycoside an
tibiotic
Resistance
High conc.
A
ztreonam
(Cayston)
Antibiotics
Inhale
Bacterial cell wall
Peptidoglycan cross-
linking
Mechanism similar to penicillin
Inhibits mucopeptide synthesis in the
bacterial cell wall by blocking
peptidoglycan crosslinking
Azithromycin
Antibiotics
Oral
50S o
f
bacterial
ribosome
Inhibit translation
AE:
- Weight gain
- Increase risk of infection with NTM
- Arrhythmia
- Deafness
Ivacaftor +
Lumacaftor
Orkambi
CFTR corrector
Potentiator
Iva:
Increase Cl
-
conductance
Luma: suppress mis-folding to increase
surface CFTR
increase surface expression of CFTR
Iva:
G551D
CIII
Luma: F508del CIII
Nintedanib
Pirfenidone
FOR IPF
Pancreatic enzyme
supplements
ENAC
direct therapy
on CFTR
Experimental
Lung
transplantation
Final
COPD
SABA
Triple therap
y
Or double therapy
LABA
uLABA
