PHRM30003 Study Guide - Final Guide: Vitamin, Liraglutide, Opioid Receptor
5 Jun 2018
School
Department
Course
Professor
Drug name
Drug cl
ass
Molecular target(s)
Mechanism/Function
Contradiction/AE/Notes
Obesity (3)
–
need to combine with ow calorie diet and exercise
Phentermine
Sympathomimetic amine
Central
Displace NA in presynaptic vesicle to increase
NA release
suppress appetite
Sho
rt
-
term use
Tolerance
Independent on VGCC
More selective to NA
AE
- Tachycardia
- Increase BP
- Insomnia
- Nervousness
- Headache
- Dry mouth
Contraindication
- Antidepressants (MAO inhibitors,
SSRI)
- Pregnancy
Orlistat
(Xenical)
Anti
-
fat absorption
Gut
(periphera
l)
Inhibits gastric and pancreatic lipases
decrease dietary fat absorption
Take with meal
Dose-dependent
AE: GIT
Must combine with low fat diet and vitamin
D&E – fat soluble vitamin
Liraglutide
GLP
-
1 receptor agonist
Multiple sites
- Increase glucose-mediated insulin
secretion
- Suppress glucagon secretion
- Slows gastric emptying
- Centrally loss of appetite/GLP1-R
AE: GIT
, pancreatitis
Sc Injection
Naltrexone+
Bupropion
Opioid receptor antagonist
Weak Ach receptor
antagonist
Stimulate POMC
alpha
-
MSH
