BCH3042 Study Guide - Final Guide: Cytokine Receptor, Signal Transduction, Transforming Growth Factor Beta
14 Apr 2020
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Sample question: discuss how enzyme-linked cell surface receptors are activated and describe the intracellular kinase cascades triggered by the activation of these receptors (50). *one* specific example of an enzyme-linked cell surface receptor pathway (50). Structure your answer use diagrams to elaborate the pathway, also dot-points. Provide a relevant example from the lectures ie her2 or men2: enzyme-linked cell surface receptors and signal transduction details: (50) Features of receptor; six major classes, name at least one rtks, list the basic domain structure. Extracellular/tm region & intracellular kinase domain, bind ligand in most cases as a dimer (10) Ligand dimer (homo- or het-dimer) induces rc dimerisation and auto-phosphorylation on tyr, Ser/thr residues due to free oh griup that accepts a -po4 group, can be multiple residues that bind different effector proteins (10) A diagram here is a good addition. Initiates binding of sh2 domain proteins to -po4 residue/ itam motif (10)
