BIO1011 Study Guide - Quiz Guide: Mendelian Inheritance, Model Organism, Gamete

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3 Aug 2018

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Was successful due to choice of a good model organism and rigorous testing. The two alleles separate into the gametes. Each gamete has a 50% chance of inheriting either allele. Gametes combine at random to form the next generation. Each pair of alleles segregates independently of others when forming gametes. Can be used to determine the genotypes of parents or offspring using phenotypes. A do(cid:373)i(cid:374)a(cid:374)t phe(cid:374)otype(cid:859)s ge(cid:374)otype (cid:272)a(cid:374) (cid:271)e deter(cid:373)i(cid:374)ed (cid:271)y perfor(cid:373)i(cid:374)g a test (cid:272)ross with a recessive phenotype. If offspring with the recessive phenotype are present, then the dominant phenotype parent was heterozygous. Crosses where phenotypes of males and females are reversed. If the results are different when the genders are reversed then the trait is sex-linked. Often used to study inheritance in humans. Can be used to determine autosomal or x-linked, as well as dominant of recessive traits. Autosomal dominant: males and females equally affected, affected individuals in multiple generations, transmission by both sexes to both sexes.

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Q 1 â Manx cats are produced when a dominant allele is inherited for the Manx gene (M). Inheritance of two dominant alleles, however, results in death of the fetus. Coat color in cats is determined by two alleles with incomplete dominance. BB produces black colored cats, Bb produces grey cats, and bb produces white cats. A grey Manx cat is mated with a white Manx. What proportion of the living offspring will be white Manx kittens? (3 points)

Q 2 â In goats, a beard is produced by an autosomal allele that is dominant in males and recessive in females. Weâll use the symbol B^b for the beard allele and B+ for the beardless allele. Another independently assorting autosomal allele that produces a black coat (W) is dominant over the allele for white coat (w). Give the phenotypes and their proportions expected for the following cross: B⁺B⁺Ww male Ã B^bB^bWw female (2 points)

Q 3 â E. W. Lindstrom crossed two corn plants with green seedlings and obtained the following progeny: 3583 green seedlings, 853 virescent-white seedlings, and 260 yellow seedlings.

Give the genotypes for the green, virescent-white, and yellow seedlings

Explain how color is determined in these seedlings (which genotype gives which phenotype). (3 points)

Q 4 â You are studying a gene that controls ossicone (horn) length in giraffes. The wild-type long-ossicone allele (L) is dominant to the mutant short-ossicone (l) allele. However the L allele is only 60% penetrant in both homozygotes and heterozygotes. In a population of 212 giraffes in an African nature preserve, 80 giraffes are either homozygous or heterozygous for the long ossicone allele (L). What proportion of offspring would you expect to exhibit the long ossicone phenotype? (2 points)

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What is a genome? What is a genome made of? Describe the bacterial genome. How do bacteria reproduce? What is binary fission? Distinguish between a chromosome and chromatin. Where are chromosomes located in eukaryotic cells? What is the chromosome made of? What is a centromere? What is the centromere's role? What are sister chromatids and how do they arise? Distinguish between somatic cells and germ (gametes) cells. Describe the cell cycle. What are the different phases? What occurs during S phase? What is interphase? How is the cell cycle controlled?

Describe mitosis. What are the phases of mitosis? What occurs in each of the phases of mitosis? What is cytokinesis? How does this differ between plant and animal cells? What is a kinetochore? Where does it form? What is its role? What is the role of microtubules in mitosis? What is a centriole and what is it composed of? What is a centrosome and what is its role in mitosis? What is the metaphase plate and why is this important? What is the mitotic spindle, its role and its makeup? What defines a diploid cell? How many copies of each chromosome is in a diploid cell? What about a haploid cell? Why do the daughter cells of mitosis always have the same complement of chromosomes?

Describe meiosis. What are the phases of meiosis? What occurs in each of the phases of meiosis? Distinguish between meiosis I and meiosis II and describe how each of these processes compare to mitosis. Why do animal cells undergo meiosis? What is a gamete? What is a zygote? What are recombination, crossing-over, and chiasma? When and why does this occur? What is meant by 'homologous pair of chromosomes'? Why don't the daughter cells of meiosis have the same genetic makeup? What controls the segregation of chromosomes into the gametes?

What are genetic characters? What are genetic traits? What is an allele? What is a locus? How many alleles at each locus would a human cell have and why? Distinguish between genotype and phenotype. What is meant by a dominant gene? What is meant by a recessive gene? How do these differ? What is the genotype of a homozygous dominant organism? What is its phenotype? What is the genotype of a homozygous recessive organism? What is its phenotype? What is the genotype of a heterozygous organism? What is its phenotype? What is a genetic cross? Distinguish between the P, F1, and F2 generations. What is a true-breeding line? What is the genotype and phenotype of a cross between homozygous dominant and homozygous recessive parents? If the F1 progeny are crossed, what would be the genotype and phenotype of the F2 generation? What would be the phenotypic ratio? What would be the genotypic ratio? Be ready to generate Punnet square tests or probability analyses of crosses involving more than one genetic locus. Describe a dihybrid cross where two alleles are homozygous dominant in one parent and homozygous recessive in the other. What would be the phenotypic ratio of the F2 generation from this dihybrid cross? What is meant by independent assortment? Be prepared to calculate probabilities resulting from different crosses.

Distinguish between complete and incomplete dominance. How would incomplete dominance alter the results of a hybrid cross? What would the resulting F2 generation phenotype and genotype ratios be? What is codominance? How does this affect the results of crosses? Be prepared to determine likely blood types of parents based on the blood types of their offspring. What is a polygenic trait? What is a carrier state for a genetic disease? What is meant by linked genes? How does this affect expected outcomes of genetic crosses? How is gene linkage used for chromosomal mapping? Distinguish between autosomes and sex chromosomes. What sex chromosomes are found in women? What sex chromosomes are found in men? What are sex-linked traits? Be prepared to give the results of crosses that involve sex-linked recessive traits. What is the process of nondisjunction? What are the likely results? Why is this important? What is a Barr body? Recognize the genetic abnormality of Downs Syndrome, Turner's Syndrome, and Klinefelter's Syndrome.

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BIO1011 Study Guide - Quiz Guide: Mendelian Inheritance, Model Organism, Gamete

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