BMS2052 Study Guide - Final Guide: Innate Lymphoid Cell, Interferon Type I, Tlr2
12 May 2018
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BMS2052 topic glossaries
Immune system glossary
• Proinflammatory cytokines (involved in leucocyte recruitment)
o IL-1 pro-inflammatory, neutrophil recruitment, IL-1 (and TNFa) activate
endothelial cells helps leukocyte recruitment.
o Il-6 lymphocyte activation, increase antibody production leads to fever,
induces acute-phase protein production
o TNF-a activated vascular endothelium and increases vascular permeability, which
leads to increased entry of IgG, complement and increased fluid drainage to lymph
nodes leads to fever, mobilisation of metabolites and shock
o IL-12 CTL differentiation, also Th1 promotion
o IL-1B activated vascular endothelium, activated lymphocytes, local tissue
destruction, increases access of effector cells leads to fever of production of IL-6
o IFN-y activates macrophages to be better killers
o Chemokines eg CXCL8 chemoattractant factor recruits neutrophils, basophils and
T cells to site of infection
o IL-2 acts in an autocrine manner which drives T cell proliferation
o IL-8 neutrophil recruitment
• Anti-inflammatory cytokines – regulate and control the immune response
o IL-10
o TGF-B
• Suppressive cytokines (in gut)
o TGF-B promotes IgA class switching
o TSLP
o PGE2
• Cytokines
o IL-2 t cell proliferation
o Type I interferon
▪ IFNa and IFNB –> antiviral
o Type II interferon INFy activation of macrophages, produced by CD4, CD8, NKC
o IL4 B cel switching to IgE, produced by CD4, mast cells
o IL5 activation of eosinophils , produced by CD4, mast, innate ymphoid cells
o IL17 stimulation of acute inflammation, neutrophil recruitment, produced by CD$
o IL22 maintenance of epithelial barrier, produced by CD4, NK, innate lymphoid
cells
o IL-12 CTL differentiation and cytotoxic activity
▪ Promotes TH1 differentiation
▪ Also cytotoxic activity in NKC
• NF-kB pathway TF that goes int the nucleus pro-inflammatory
• TILRs (PRR type) extracellular
o TLR1:TLR2 bacterial lipopeptides eg Gram +ve bacteria; S.aureus
o TLR 2 bacterial peptidoglycan
o TLR4 LPS eg Gram -ve bacteria; E.coli
o TLR5 bacterial flagellin eg flagellated bacteria; V.cholerae
o TLR2:TLR6 bacterial lipopetides eg Gram +ve bacteria; mycobacterium
• TLRs intracellular/ endosomal
Document Summary
Immune system glossary: proinflammatory cytokines (involved in leucocyte recruitment) Il-1 pro-inflammatory, neutrophil recruitment, il-1 (and tnfa) activate endothelial cells helps leukocyte recruitment. Il-1b activated vascular endothelium, activated lymphocytes, local tissue destruction, increases access of effector cells leads to fever of production of il-6. Ifn-y activates macrophages to be better killers: chemokines eg cxcl8 chemoattractant factor recruits neutrophils, basophils and. Il-2 acts in an autocrine manner which drives t cell proliferation. Il-8 neutrophil recruitment: anti-inflammatory cytokines regulate and control the immune response. Il-10: tgf-b, suppressive cytokines (in gut, tgf-b promotes iga class switching, tslp, pge2, cytokines. Il-2 t cell proliferation: type i interferon. Ifna and ifnb > antiviral: type ii interferon infy activation of macrophages, produced by cd4, cd8, nkc. Il4 b cel switching to ige, produced by cd4, mast cells. Il5 activation of eosinophils , produced by cd4, mast, innate ymphoid cells. Il17 stimulation of acute inflammation, neutrophil recruitment, produced by cd$
