IMED1002 Study Guide - Final Guide: Wild Type, Missense Mutation
IMED1002 Revision Notes 221
Suppressor mutation
● It “hides”
○ the effect of another mutation
● Distinct to reverse mutation
○ in which the mutated site:
■ changes back to original WT sequence
● Occurs at a site
○ distinct from the site of the original mutation
■⇒ Double mutant
More on suppressor mutation
● It is a second mutation
○ It alleviates/reverts the phenotypic effects
■ of an already existing mutation
● Process:
○⇒ synthetic rescue
● Genetic suppression
○ restores the phenotype
■ seen prior to the first mutation
Reverse mutations
● Get wild type!
○ Conversion direction
■ Mutant → wild type
