IMED2001 Study Guide - Final Guide: Helper Virus, Daptomycin, Folic Acid
30 Jun 2018
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IMED2001: Revision Notes 10
Lipopeptides:
-Antibiotics class associated with cell membrane (made of lipids)!
-Daptomycin (type of lipopeptides) !
-= inserts itself into lipid membrane !
--> depolarization -> K+ ions leak out!
4 major chemicals involved in inflammation:
1) Histamine!
2) Prostaglandins!
3) Kinins!
4) Leukotrienes!
Class of antibiotics associated with folate synthesis (inhibition)
-affects DNA replication!
-Sulfonamides (sulfamethoxazole)!
Cross presentation:
-goes from class 2 to class 1 MHC !
-(exogenous peptide presented by MHC class 1 to CD8+ T cells)!
-WHY CROSS PRESENTATION? !
-Many viruses do not infect DC !
-so cannot be processed by MHC1 straightaway!
-Once endogenous antigen in cell:!
-Instead of going through lysozyme degradation, it undergoes proteasome degradation!
-Follows through with MHC1 pathway!
Must be specific peptide to be loaded onto MHC then present it for T cells
Co-dominance:
-inherit alleles from parents!
-no preferences of allele to present certain HLA to the other !
-= equally expressed !
Immuno-dominance:
-Peptides bind bests to certain MHC1/2 molecules !
-= immuno-dominance (relates to how certain peptides specific to MHC molecules)!
T cell activation:
-Signal 1: !
-presentation of peptide via MHC molecule to interact with T cells!
-Signal 2: !
Document Summary
Antibiotics class associated with cell membrane (made of lipids) -> depolarization -> k+ ions leak out. 4 major chemicals involved in in ammation: histamine, prostaglandins, kinins, leukotrienes. Class of antibiotics associated with folate synthesis (inhibition) Goes from class 2 to class 1 mhc. (exogenous peptide presented by mhc class 1 to cd8+ t cells) So cannot be processed by mhc1 straightaway. Instead of going through lysozyme degradation, it undergoes proteasome degradation. Must be speci c peptide to be loaded onto mhc then present it for t cells. No preferences of allele to present certain hla to the other. Peptides bind bests to certain mhc1/2 molecules. = immuno-dominance (relates to how certain peptides speci c to mhc molecules) Presentation of peptide via mhc molecule to interact with t cells. Co-stimulation by cytokines (eg. binding of lps to tlrs) H: responsible for attachment to sialic acid on epithelial cells of respiratory tract. (eg. hep d) need helper virus (eg.
