HMM103- Midterm Exam Guide - Comprehensive Notes for the exam ( 42 pages long!)
Document Summary
From when it is created to when it gives rise to 2 daughter cells. There are 4 phases: g1 (gap 1), s (synthesis), g2 (gap 2) and m (mitosis). Interphase is the entirety of cell cycle outside m. Already duplicated chromosomes (2 sister chromatids) are held together by a centromere. Metaphase: the nuclear membrane disappears and chromosomes become distinct. Mitotic spindles reach to the centrioles at the ends of the cell. Anaphase: 2 sister chromatids separate at the centromere and pulled to opposite poles by the spindles. Telophase: the spindle disappears as the chromosomes decondense and return to chromatin. Cytokinesis: constriction separates cytoplasm until there are 2 independent daughter cells. Asynchronous: does not synchronise and are all at different cycles. Microtubule antagonist (eg. colcemid): cells will go into metaphase but cannot assemble spindle fibres and therefore will remain at metaphase, synchronising the cells. E. g. (cells in mitosis/all cells) x 24 hours = length of cell cycle. (4n-2n)