BIOL2200 Study Guide - Midterm Guide: Ubiquitin, Proteasome, Alkanolamine
Document Summary
Phosphorylation vs ubiquitination: p: temporary, reversible, reversal takes milliseconds, u: permanent, irreversible, protein is destroyed so must start again from transcription which may take hours. Cyclin-dependent kinases (cdk: heterodimeric protein kinases drive cell cycle, 2 protein subunits (cyclin + cdk) bound to each other making an active enzyme. Cyclin: cyclin-regulatory subunit: cyclical (expressed at specific cell cycle stages - peaks between g1 and s phase, activates cdk when bound. Specific cyclins are made at specific times and determines. Cdk specificity: recognises which type of cdk to bind to. Cdk: cyclin dependent-kinase: always present but inactivated by default, only activated when bound to cyclin, when bound, phosphorylation can occur, can bind to several types of cyclin. Cdk-cyclin: hundreds of proteins are targets, regulate different cell cycle transitions (different ones at each phase) 2: cdk-cyclins can be referred to as cdks (from now on)
