PCOL2012 Study Guide - Final Guide: Central Nervous System Depression, Proton-Pump Inhibitor, Omeprazole

• School: University of Sydney
• Department: Pharmacology
• Course: PCOL2012
• Professor: All

Document Summary

Ion channels: ion channels = allow ions (eg: na+, ca2+, k+) to cross membranes. May be voltage-gated or ligand-gated (also a type of receptor: blockers = prevent ions from passing through channel, modulators = increase or decrease the opening probability of the channel (but do not block) How drugs work: examples: drugs agonize (activate) receptors. Example: salbutamol- 2 agonist used in asthma to relax bronchial smooth muscle and oppose bronchoconstriction: drugs antagonize receptor. Example: atenolol- 2 agonist which antagonizes the action of. Na, decreasing heart rate and reducing blood pressure: drugs block ion channels. Example: lignocaine- blocks na+ channel to prevent the transduction of pain signals across nerve cells (local anesthesia: drugs inhibit enzymes. Example: asprin- inhibits enzyme cyclooxygenase, which prevents prostaglandin production, causing analgesia and reducing inflammation: drugs inhibit transporters. Example: fluoxetine- inhibits serotonin/5ht uptake into nerve cells in the cns, increasing synaptic concs of 5ht (used to treat depression)