PHSI2006 Study Guide - Final Guide: Tubuloglomerular Feedback, Afferent Arterioles, Myogenic Mechanism

• School: University of Sydney
• Department: Physiology
• Course: PHSI2006
• Professor: phsi2006

Document Summary

3/07/2016 1:20 pm: gfr= kf (filtration coefficient) x net filtration pressure nfp, filtration coefficient relates to permeability and surface area of the filtration barrier. This contraction maintains the blood flow into the glomerulus: if bp decreases, the tonic level of arteriolar contraction disappears and the arteriole becomes dilated to let more blood through. Under 80mmhg bp, gfr decreases which is good cos it conserves water: tubuloglomerular feedback. The fluid flow through the tubule influences gfr: junction between the thick ascending limb and the distal tubule. This whole structure is called the juxtaglomerular apparatus. This is called the na+k+-2cl- cotransporter (or triple cotransporter): the epithelial cells on the ascending limb close to the arterioles are specialised epithelial cells called macula densa cells. They can respond to the amount of the ions that is transported into these cells. The macula densa cells respond to the rate of transport of chloride which depends on the amount of cl in the lumen.