IMED2003 Study Guide - Midterm Guide: World Medical Association, Nuremberg Code, Organoarsenic ChemistryPremium
2 pages66 viewsSpring 2018
DepartmentIntegrated Medical Sciences
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IMED2003: Revision 14 Notes
Declaration of Helsinki (1964): ADDITION TO NUREMBURG CODE
⇒ ETHICAL PRINCIPLES FOR MEDICAL RESEARCH INVOLVING HUMAN
● The World Medical Association drew up the first version of the DoH that
broadened the concerns of the Nuremberg Code
○ Significant additions include:
■ ‘Right to ‘privacy’
■ Confidentiality of personal information of research subjects
■ Privacy regarding the use of identifiable human information
■ Seven revisions, with the last (64th WMA General
Assembly) in 2013
Human Use of Human Beings:
○ Norwegian study
○ Reported on the pathologic manifestations of untreated syphilis in several
hundred white males.
Tuskegee Syphilis Experiment (1932-1972)
○ Designed as a prospective study to complement Oslo
○ Initially not inherently unethical in 1932- no cure was available.
○ Involved 6-8 months observation and then contemporary treatments such
as Salvarsan (organoarsenic), mercurial ointments, and bismuth (possibly
mildly effective, but very toxic).
○ Men were actively prevented from accessing treatment and exiting the
○ The dependent variable in the Tuskegee Experiment (ie unknown), was
whether persons with syphilis were better off without the ‘treatment’.
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