PHYL2001 Study Guide - Final Guide: Hypothalamus, Labioscrotal Swelling, Genital Tubercle
Reproductive Physiology
Sexual Differentiation:
• Genetic sex → predetermined by configuration of the sex chromosomes
→ XX or XY
• Gonadal sex → determined by sex chromosomes → Y or no Y
• Anatomical sex → dependent on gonadal sex and hormones (i.e.
androgens)
• Development of gonadal sex
• Development of external genitalia
o 5� reductase deficiency → Penis at syndrome → enlarged
clitoris
o No testosterone receptors → androgen insensitivity syndrome →
female-like external genitalia
o Genital tubercle develops to
▪ Clitoris (females)
▪ Glans (males)
o Urethral folds and labioscrotal swellings respectively develop into
▪ Labia minora/majora (female)
▪ Urethra and scrotum (male)
o Urogenital slit develops into
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