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BIOL 1003 Quiz: BIOL 1003 Nov.30 .docx

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BIOL 1003
Iain Mc Kinnell
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BIOL 1003 Nov. 30
Sex linkage of genes, 22 pairs of autosomes and 1 pair of sex chromosomes
Sex genes are not sex functions
Most are phenotypic traits
They don’t follow Medellian ratios
Try to understand human sex linked disorders
Most occurrence in males for sex linked disorders
oMale only have one X chromosome therefore he will show phenotype and
female needs both recessive allele from both parents
oTransmission of mode is important: a male cant pass it off to offspring
oThe male doesn’t pass disease onto male, only female since its X
oSkips generations in the male line, grandson can receive sex linked disease
oDaughter can be carrier and pass it onto son
oAll related to testes in the male (incomplete)
oIn absence of another allele, you will observe in phenotype, masks effect
of recessive allele, if there is no dominance
oAbsence of second allele instead of flipping
Hemophilia: excessive bleeding
oMutation in clotting protein
oThere are different types: A (1 in 7500) and B
Red-green colour blindness
oMost common type of colour blindness
oGene that controls production of photo-pigments
Duchenne muscular dystrophy
oWeakening of the muscles and loss of coordination
Hemophilia: stems back to royal times in Victorian times
oQueen Victoria, started with her; extreme intermarriage
oShe was a carrier of hemophilia; could’ve been spontaneous mutation or
from parents
oOne good allele and one was mutant for hemophilia, had 50/50 chance of
passing it on
oRecessive allele carried on X chromosome and males show symptoms
oFemale heterozygous carriers don’t show symptoms and homozygous do
show symptoms
oRasputin told family to leave Alexis anymore and he become very
powerful, leading to Russian Revolution
oAll the boys in the family got hemophilia; hallmark of x-linked mutations
X-linked dominant diseases
oCongenital generalized hypertrichosis
oExcessive hair growth
oEnded up in the circus
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