CHEM 1AA3 Study Guide - High-Throughput Screening, Aromaticity, Pi Bond

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Queen phermone blocks aversive learning in young worker bees. Qmp contains homovanillyl alcohol (hva: hva supresses bad memories, but not good ones. Biological role: mitigates unpleasant side effect of qmp. Hva interrupts negative memories / side effects. Significance: hva lowers [dopamine, dopamine is associated with learning. Therapeutic potential: high [dopamine] isn some psychoses & schitzophrenia, hva-like molecules could be treatments but need high specificity. Add and parkinsons disease are linked to low [dopamine] Global suppression of [dopamine] or suppression in the wrong part of the brain, could have undesired side effects. Queen bees control worker bees" memories using hva. 1 new drug requires ~5000 failed compounds, therefore improving synthesis and accelerating assays facilitates drug discovery. High-throughout screening (hts: fast way to assay for a complex biological response. 2 components: a fast assay, massively parallel assays. Instead of doing experiments on live bees, use dopamine-producing bee neural cells growing in cell culture. 96 well microtiter plates allow 96 simultaneous assays.