MBB 222 Study Guide - Final Guide: Leucine Zipper, Structural Motif, Electronegativity
Document Summary
Mbb222 exam vocab definitions: transcription factor interfaces, combinatorial. Control, e. coli dna replication fork and replisome (dna polymerase domain) An independently folded protein domain that contains at least one structural motif that can recognize double or single stranded dna. To bind specifically to dna sequences, regulatory proteins must recognizes surface features on the dna. Most specificity is due to the recognition of hydrogen bonds (h-bond donor and acceptor groups) Major groove has more specificity than minor groove because more chemical information is present on major groove. An alpha-helix for binding with dna at a major groove. Functional groups in the major and minor groove of dna. Includes: h-bond acceptor, h-bond donor, other h and methyl group. Major groove has more chemical information (4 groups vs. 3 on minor groove) An acceptor is an electronegative atom with no h attached. A donor is an electronegative atom with an h attached.