KNES 260 Study Guide - Final Guide: Renal Function, Respiratory Acidosis, Distal Convoluted Tubule

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6 kidney functions (wastes, h2o balance, bp renin, acid-base, erythropoietin, vitk vitd). 1m nephrons/kidney, 2 types cortical (short, 85%) & juxtamedullary (long, 15%, osmotic gradient in loop of henle for reabsorption) Bowman"s glomerulus (fenestrated capillaries) proximal henle (descending = 3 processes: secretion (into tubule), reabsorption (into blood), glomerular filtration. Facilitated by peritubular capillaries (run with tubules) substances have 3 fates: 1) filtered + secreted (alcohol), 2) filtered + reabsorbed (glucose), 3) filtered + somewhat reabsorbed (na+) Glomerulus = 160-180 l per day, no rbc"s/proteins, reabsorb na+/cl-/ca2+/po4/h2o/glucose, secrete k+/h+/big organics, <1% urine! 3 glomerular layers: glomerular capillary wall basement membrane (collagen + glycoproteins) bowman"s (podocytes change) 3 filtration forces: glomerular bp (for), plasma-colloid osmotic pressure (against), bowman hydrostatic pressure (against). Filtration depends on net pressure, glomerular sa, podocytes. Badly burned = gfr, dehydrating diarrhea = gfr. Vasoconstrict aa and/or vasodilate ea = gfr. Gfr intrinsic/direct control: 1) myogenic (stretch reflex), 2) tubuloglomerular feedback (paracrine, macula densa), slit size.

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