ANSC 4650 Final: Immuno Final Notes
21 Oct 2016
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Document Summary
= effector cells of the innate immune system. = play key role in tissue repair during resolution. = tissue macrophages mainly derived from circulating monocytes recruited to infected/damaged tissue. *previously tissue macrophages referred to as sentinel cells. Macrophages= just as important as effector cells of the innate inflammatory response and cell-mediated imr. = = bridge between innate and acquired immune systems. *similar to neut extravasation but involved monocyte specific chemokines and adhesion molecules. During extravasation and chemotaxis, monocytes differentiate into effector cells = macrophages. Macrophages have sustained phagocytic activity and longer life span than neuts = more efficient effector cells. Monocyte extravasation designed to occur immediately following neutrophil influx . - such as (cid:574)-defensins, chemerin, tnf- (cid:573) from activated neutrophils. Monocyte infiltration is also dependent expression of monocyte-endothelial cell adhesion molecules: Tethering molecules: endothelial cell p-selectin; monocyte p-selectin glycoprotein ligang (psgl-1) Rolling molcules: endothelial cell e-selectin; monocyte cd62l (l-selectin)
