BIOC 2580 Study Guide - Midterm Guide: Van Der Waals Force, Triosephosphate Isomerase, Helix Bundle

• School: University of Guelph
• Department: Biochemistry
• Course: BIOC 2580
• Professor: Dawson S Graether

Document Summary

Collagen structure requires sequence with repeating units of 3 aa. Close contacts attract by weak van der wall forcers (london dispersive forces) Clusters of 2-3 secondary structure breakers (gpnds) in a run of 4 aas. Allows flexible loops and turns where pp can change direction to allow folding. Requires breaks in secondary structure, which is rigid. Collagen (tendon, bone & ct) = unique triple helix. Secondary structure is rigid, so these are fibrous secondary proteins . Tertiary structure = overall pattern of folding of whole pp chain. Simplest possible tertiary structure is continuous secondary structure. Side chains interlock to maximize number of close atom-to-atom contacts. Good fit makes hundreds of close contacts in macromolecule. The way a protein folds is dictated by the sequence of its aas. Large and small side chains arranged so secondary structure components pair up. Balancing act of many forces for protein to reach stable native state.