BIOC 4580 Final: BIOC 4580 Class 27 notes
21 Mar 2017
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Bioc 4580 class 27- membrane trafficking- secretion and endocytosis. Review of some aspects of vesicular pathways, including cytoskeletal highways, and introduce some of the coat proteins that are involved copi, copii, clathrin, & caveolin. Constitutive & regulatory secretory pathways will be compared. Four examples of receptor-mediated endocytosis will be described: delivery of ldl & transferrin to the cell, modulation of responses to insulin, recycling of serum glycoproteins & autophagy, entry of enveloped viruses. Overview of secretory and endocytic pathways of protein sorting. *step 8: recall ph-induced dissociation, separation, sorting and recycling of mannose-6-phosphate receptors from last lecture. Permeant (able to pass through or into a membrane) amines can disrupt these steps. Protein is transported by way of actomyosin highways. Myosin & kinesin co-operate in vesicle transport at the cell cortex, whereas kinesin and dynein do so in the cell body. Secreted protein vesicles jump from microtubules to microfilaments to get closer to the cortical actin cell membrane.
