[BIOL 1070] - Midterm Exam Guide - Comprehensive Notes for the exam (50 pages long!)
6 Feb 2017
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Document Summary
Membranes define the cell maintains an inner and outer environment and gradient: compartmentalization impermeability, surface functions adhesion, recognition, communication signal transduction, trafficking, cell shape and motility, functional proteins within lipid matrix. Overton 1900: proposed idea of a semi-permeable (only permeable to water) lipid-rich membrane with. Langmuir 1917: proposed idea of asymmetric shape of membranes with 2 regions: hydrophobic and hydrophilic (monolayer) Langmuir-troph experiment spreading lipids on a surface, hydrophobic regions are on top facing the air, hydrophilic regions are in contact with the liquid below. Gorter and grendel 1925: proposed idea of lipid bilayer using erythrocytes and the langmuir-troph apparatus to measure the surface layer (discovered layer of fatty substances that is 2 molecules thick) Mid-20th century: tem and basic structure showed triple track structure, suggested all membranes have same basic structure. Differences in composition are related to differences in function. Myelin: rich in lipid, low in protein. Mitochondrial inner membrane, bacterial cytoplasmic membrane: rich in protein, low in lipid.
