MCB 4010 Study Guide - Midterm Guide: Sh2 Domain, Phosphoinositide 3-Kinase, Grb2
Document Summary
Su : binding of gtp to g triggers dissociation of g both from the triggering dissociation of gdp receptor and from g , hormone bound receptor can interact with additional g proteins. Receptor/ligand complex acts as a g protein gef (guanine exchange factor: gdp release, gtp binds g , g is active, binds effector. In the dark, high levels of cgmp keeps nucleotide gated cation channels open: light absorption generates active opsin (o*, o* binds g t gdp activating it, g t gtp releases from g , g t gtp activates cgmp phosphodiesterase (pde) by binding to inhibitor sus, active pde converts cgmp to. Gmp: decreased [cgmp] results in dissociation of cgmp from nucleotide gated channels causing the channels to close hyperpolarization neurotransmitter release membrane reduced. Grks: 7 members in humans, each grk is receptor specific [e. g. rhodopsin kinase, adrenergic receptor kinase ( ark): some grks shuttle between, prolonged exposure to ligand leads to non responsiveness (or weakened signal)