NUTR 3330 Study Guide - Final Guide: Cobalamin, Angular Cheilitis, Pyridoxine
26 Feb 2015
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Acid, cobalamin (b12: 8 b vitamins, choline, vitamin c, vitamin d, vitamin k, vitamin e, vitamin a, beta carotene. Deficiency: beri beri (3 types: wet, edema, heart swelling, pulmonary congestion, dry, no edema, cns impairment, alcoholics (wernicke korsakoff syndrome, confusion, memory loss. Nad(p)h(cid:224)nad(p) synthesis of fatty acids and steroids: pentose phosphate pathway, alternative route of glucose metabolism, 2 purposes, generate nadph for synthesis of fa & steroids, generate ribose for synthesis of nucleic acids. Think egg white: free biotin, ureido ring, sulphur ring, valeric acid sidechain, biocytin (protein bound biotin, biotin + lysine, step in proteolysis during biotin digestion, biotin binds to enzymes via lysine (holocarboxylase) Biochemical results of biotin deficiency: decrease in biotin dependent enzymes, decreased pyruvate carboxylase, decreased gluconeogenesis, increased pyruvate and lactate(cid:224)less glucose produced, decreased accoa carboxylase, build up of acetyl coa; risk of ketosis, impaired serum lipids.
