NUTR 4210 Study Guide - Final Guide: Intramuscular Fat, Sarcopenia, Skeletal Muscle
15 Dec 2016
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Leads to neuromuscular impairment, loss of mobility, balance problems, i(cid:374)(cid:272)reased falls & fra(cid:272)tures, i(cid:373)(cid:373)o(cid:271)ilizatio(cid:374) . Disease is only evident once a threshold is reached. Use imaging techniques to diagnose (could have normal bmi but low muscle mass) Sarcopenia: skeletal muscle mass 2 or more standard deviations below sex-specific mean for young healthy adult. Not just loss of muscle mass, but loss of strength too. Muscle mass does not equal muscle function. Decline in strength exceeds what is expected based on decline in mass. Ca(cid:374)t deter(cid:373)i(cid:374)e fu(cid:374)(cid:272)tio(cid:374)al (cid:272)apa(cid:272)ity (cid:271)ased o(cid:374) (cid:449)hat"s (cid:271)ee(cid:374) lost. Decline in muscle quality (force per unit of cross sectional area) High quality: high oxidative capacity, high glucose transport capacity, high lipid transport capacity. Becoming more prevalent: population is aging and there is an obesity epidemic! Agai(cid:374), (cid:272)a(cid:374)"t tell (cid:271)y looki(cid:374)g at a(cid:374) o(cid:271)ese perso(cid:374) if they ha(cid:448)e so. Fat mass increases from birth, peaks around 60-75. Differences in where adipose tissue is stored.
