PATH 3610 Study Guide - Final Guide: Synovitis, Glycoprotein, Menopause

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Contain hematopoietic cavities in the marrow (blood cell production) Inorganic: 65% (more than just calcium and phosphorus) Intramembranous ossification: occurs in fibrous tissue: produce large amounts of bone, may get incorporated into matrix to form osteocytes. Osteocytes: role in mineral metabolism, remove small amounts of bone in immediate vicinity. Osteoclasts: derived from macrophages, remove bone. Interaction between osteoblasts and osteoclasts is essential to remodel bone. Bone is continuously being replaced and remodeled (how microfractures heal), insures you always have good bone in your body. Lamella: bone that has been present for a long time, is multilayered and arranged in columns (osteons), contain bone marrow. Parathormone which tells osteoclasts to remove mineralized bone: produced by parathyroid gland, stimulates osteoblasts and stromal cells to express rankl (rank ligand), osteoclasts have rank, binds rankl, osteoclastic resprotion releases calcium into circulation, osteoprotegerin: binds pank, inhibits rankl. Calcitonin: produced by the thyroid gland, reduces blood calcium by stimulation its incorporation into bone, inhibits osteoclasts.

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