MCIM 308 Study Guide - Final Guide: Terbinafine, Ileum, Tinea Cruris

• School: U of S
• Department: Microbiology and Immunology
• Course: MCIM 308
• Professor: White Aaron

Document Summary

O poly, core poly, and lipid a. After ingestion, salmonella attacks m (microfold) cells in small intestine mucosa. Can go across cytoplasm to the blood. Two pathogenicity islands pai 1 and pai ii. Pai i has salmonella secreted invasion proteins (ssps) and t3ss to inject proteins in host cell. Pai ii is for immune evasion, uses t3ss. High dose of 10^6 to 10^8 required for infection. Most common by typhi, paratyphi and choleraesuis. Bacteria escapes lining of gut, and engulfed by macrophages. They replicate and transported to liver, spleen, bone marrow. Causes typhoid fever and then later gastrointestinal symptoms. Gram ve facultative anaerobic rods fermenter, oxidase negative. Shigella attaches to m cells in peyer patches in colon. T3ss secretes 3 proteins: ipaa, ipab, ipac, ipad into epithelial cells and macrophages, leading to engulfment. It then lyses out of the vacuole and uses actin filaments, for cell-to-cell passage. Also induces apoptosis to protect from phagocytosis.