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BIOL239 Study Guide - Blood Type, Genetics (Journal), Gregor Mendel


Department
Biology
Course Code
BIOL239
Professor
Christine Dupont

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GENETICS REVIEW
Mendelian Genetics
Belyaev artificially bred foxes ... happy foxes vs. Aggressive foxes
Gregor Mendel
Laws of inheritance
Experimented with garden peas
Why Garden peas?
Easy to cross fertalize
Large numbers of offspring
Short growing season
Terms:
Phenotype observable characteristic, can also be behaviour, referred to as a trait
Genotype- genetic make-up, version of the gene
Monohybrid cross matings between individuals that only differ one trait. Example tall
vs short, yellow vs green.
Gene - unit of inheritance. Example: one gene in humans for eye colour.
Allele alternative form of a single gene. Example: ^ multiple versions of eye colour.
Polymorphic more than one wiltype allele, allele frequency greater than 1%, several
alleses that occurs normally in a population.
Monomorphic only one wild type alle, only one allele above 1%, one alle that is
normally present in a population. Example: sickle cell anemia.
Mendel’s Experiment
Used selective breeding to produce true-breeding lines of peas
Found a consistent pattern of inheritance
Mendel’s Law of Segregation:
The two alleles for each trait separate (segregate) during gamete formation, then unite at
random, one from each parent at fertalization.
At the DNA level, alleles vary in nucleotide sequence. This can result in:
o New amino acid sequence
o Change in amount of protein

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o Example: garden peas. R gives the pea a round shape because the version of starch
branching enzyme is normal. The r allele as a different amino acid sequence and the
enzyme is non-functional (ie. No branched starch)
Mendel’s Law of Independent Assortment
During gamete formation, different pairs of alleles segregate independently of each other.
Dominant allele G does not always travel and pair with dominant W.
Law of Segregation describes how different alleles of a gene behave. Law of independant
assortment describes how different genes behave.
Monohybrids
Phenotypic ratio: 3:1
Genotypic ratio 1:2:1
Genetic Crosses
To determine genotype, use a test cross.
Test crosses breeding an unknown genotype with a homozygous recessive indivudal
will reveal it’s genotype. If it was homozygous dominant, all offspring would be
heterozygous and have the same phenotype. If it was heterozygous, we would see a 1:1
phenotypic ratio.
The law of product: The probability of two or more independent events occurring
together is the product of the probabilities that each event will occur by itself. AND IS
KEY WORD.
Example: coin toss chance of heads twice in a row. Probability of a head and a head. ½
x ½ = ¼
The law of sum: The probability of either of two mutually exclusive events occurring is
the sum of their individual probabilities. OR IS KEY WORD.
Example: dice throw chance of an even number = probability of a 2, 4, or a 6. 1/6 + 1/6
+ 1/6 = ½.
Dihybrid Crosses Matings between individuals that differ in two traits. There are more
phenotypic classes seen because there are more allele combo’s for independant
assortment. 9:3:3:1 phenotypic ratio.
Multihybrid Cross Matings between individuals that differ in three or more traits. Eg.
Aa Bb Cc Dd x Aa Bb Cc Dd ... branching diagram, or... probability of an AA bb Cc Dd
offspring : ¼ x ¼ x ½ x ½ = 1/64
-Modifications of Mendels Ratios
Crossing When a gene has more than 2 alleles, reciprocal crosses help determine
dominance relationships by crossing pure breeding lines.
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