BIOL273 Study Guide - Final Guide: Innate Immune System, Natural Killer Cell, Humoral Immunity
Document Summary
Secondary lymphoid organs: spleen, lymph nodes, tonsils, and gut associated. Neutrophils- 50-70%, can leave circulatory system to attack pathogens in tissues, granules contain cytokines that cause fever and start other inflammatory responses. Monocytes/macrophages- 1-6%, monocytes move into tissue to become macrophages, macrophages scavenge by phagocytosing old rbc and dead neutrophils, acquired immune response-phagocytosed pathogens are digested and fragments are placed on the cell surface (apcs) Lymphocytes-20-30%, only 5% in circulation, most in lymphoid tissues, key players in acquired immune response. Cell-mediated immunity (nk cells, tcells, bcells) vs humoral immunity (antibodies) Professional phagocytes differ from other cells because they will destroy or suppress the invader by ingesting it. Chemotaxins are chemicals that attract other immune cells. Cytokines and other immune blood proteins secrete them to attract immune cells, products of tissue injury secrete them to attract clotting, and bacterial products. Opsonins are taggers which bind to pathogen for phagocytes to find.
