BIOL303 Study Guide - Final Guide: Homeotic Selector Gene, Receptor Tyrosine Kinase, Morphogen
3 Oct 2017
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Document Summary
Bicoid mrna injected back into a bicoid mutant embryo induces head structures regardless of the site of injection. Bicoid mrna injected into the head of bicoid mutants achieved full rescue and a large amount of bicoid mrna injected into the posterior of a wild-type resulted in head formation at both ends. Evidence suggesting that bicoid functions as a morphogen found in embryos which had been genetically modified to vary the dosage of the bicoid gene. Increasing doses causes the anterior region to expand to the posterior; the location of the cephalic furrow moves closer to the posterior with more bicoid. The general idea is that oskar mrna is transported to mt plus ends by kinesins and takes a protein called staufen along with it. At the posterior pole, oskar mrna and staufen protein bind to cortical actin filaments and oskar mrna is translated.
