BIOL432 Study Guide - Midterm Guide: Microparticle, Nucleoprotein, Immunodeficiency
Document Summary
Recombinant vaccines: traditional vaccines consist of, killed, attenuated, live, limitations, not all infectious agents can be grown in culture, production requires animal cell culture (cid:224) expensive, yield and rate of production (cid:224) expensive, safety precautions, may not be killed efficiently or attenuated so can introduce virulent, attenuated strains my revert (cid:224) requires continual testing, not all are preventable with the use of vaccines, limited shelf life of vaccines. Edward jenner and louis pasteur developed vaccines against smallpox (1770) and anthrax and rabies (1870s and 1880s): takes so long for new vaccines to come to market, 25 major vaccine producers in 1970 (cid:224) now 5 big guys bought out little guys, vaccines viewed as commodity (cid:224) 16 billion to develop new vaccines, us government is major purchaser of vaccines (cid:224) discount prices decreasing potential profit, transition from conventional to newer processes for vaccine production is expensive and time consuming (not including clinical trials)