KIN 210 Midterm: test 3 -1
26 Sep 2017
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Document Summary
Senescence cells cannot proliferate anymore: factors: lifestyle > genetics > generation, aging is composed of: exponential increase in mortality with age. Physiological changes to a functional decline with age increased susceptibility to certain diseases with age. Ted talk: daf 2-mutant genes are switched on that promote protein repair & synthesis, decreasing activity of igf-1 (growth) makes them live longer, foxo gene activating multiple genes in processes in maintenance and repair. Limited energy balanced between the reproductive activities and the somatic maintenance. Organism die/evolution under natural selection focus on reproduction and age faster. Energy costs in maintaining our body in working order (division of labour b/w germ and somatic cells) High correlation with high hdl and low ldl cholesterol levels variant in cetp gene. Foxo3 variants also correlated with longevity in japanese: env variables. Exposure to toxins (increased cancer risk, endocrine disruption) Social determinants (ses, access to health care) Gh resistance: laron syndrome mutations in ghr, role of foxo.
