KIN404 Midterm: TEST 3 NOTES- Regulation of energy storage.docx

• School: University of Waterloo
• Department: Kinesiology
• Course: KIN404
• Professor: Russ Tupling

Document Summary

Current understanding of the signaling pathways involved in glut4 translocation with insulin or contraction. In the fasted state there"s no glucose, so there"s no muscle glucose uptake either: gsv are sequestered inside the cell due to the action of as160 protein, which contains a. Rab protein domain that binds gtp: when as160 is activated, that"s when insulin is not present, therefore fasted state, and it promotes the hydrolysis of gtp to rab-bound gdp. This is what prevents the gsv from translocating to the cell surface membrane. Gtpase activity of rab which leads to increased movement and fusion of glut4 storage vesicles (gsv). Activation of akt and apkc leads to the phosphorylation of as160. Rab gtp cannot be converted to rab gdp. As160 is the convergence point for both pathways. The different effects of the pathways and their additive effect could be because there are different isoforms for each pathway.